Do you know that walnut contains super nutrients which can suppress 13 types of cancer from growing!

Have some walnuts every day; make the cancer shrink and decay?! Article written by Bernadette Yu, R.TCMP, R.HN

Other than loaded with vitamins, minerals and omega-3 fatty acids which are good for your cholesterol and heart health, medical researchers found that walnut contains many types of unique cancer fighting polyphenols, protein peptides and bioactive components that that can stop cancer stem cell from self-renewing. So, what would you say if I told you that eating walnuts may actually help you fight off cancer?

Let’s look into this further.

5 of the most recent scientific studies showed walnut’s super power in killing and suppressing cancer growth!

Medical Research #1 (published Sept 2016) [1]

Walnut contains 20-25% protein. With an increased global demand for walnut oil and a lack of demand for the walnut flesh, the flesh which is rich in protein, becomes waste. To find out if this protein can provide any medicinal value and increase the cancer killing potency of existing chemotherapeutic drugs, a cancer research project collected walnut protein waste. They tested it against the viability of two different cancers. One being a type of human breast cancer (MDA-MB231) and another one is a type of colon cancer (HT-29). The result was surprising!

The scientists were able to identify a peptide fraction that inhibits the growth of both breast cancer and colon cancer cells. They were able to see a 61-65% growth reduction for the type of breast cancer (MDA-MB231) and a 50-52% growth reduction for the type of colon cancer (HT-29).

The significant outcome of this project is that the scientists are able to prove the cytotoxicity of walnut protein against breast (MDA-MB231) and colon (HT-29) cancers. What does the result imply? That protein from walnut flesh may provide a promising cure for breast and colon cancers!

Medical Research #2 (published July 2016) [2]

Colorectal cancer is the third leading cause of cancer deaths in U.S. Despite advances in colorectal cancer screening, as well as surgical resection and chemotherapeutic drug therapy, there is a 50% of cancer recurrence rate. The high colorectal cancer recurrence rate is highly correlated to the Cancer stem cell’s (CSC) ability in self-renewal (replace, rebuild and repair), differentiation (generating multiple or specializing cell types) and generating tumors (tumorigenicity). These functions of the cancer stem cell make the cancer cells become chemotherapeutic drug-resistant, anti-radiation, highly proliferative and invasive; and even increase their ability in metastasis (spread and develop in various part of the body).

In this cancer study, researchers targeted the cancer stem cells in their experiments to investigate a potential therapeutic approach to treat colorectal cancer (CRC) with the use of polyphenols, some naturally occurring substances which exist mainly in the Plant kingdom.

Many types of polyphenols are known to have anti-carcinogenic properties, some of which can inhibit cancer growth and some induce cancer cell death (apoptosis) and some directly suppress cancer stem cell activities and functions. Walnut, as it contains many types of polyphenols which are known for their anti-carcinogenic properties, was selected in this study.

During the experiment, the researchers extracted a spectrum of bioactive phenolic compounds from walnut. They named this compound “Walnut Phenolic Extract”. The major phenolic compounds within the “Walnut Phenolic Extract” include gallic acid, (+)-catechin, clorogenic acid and ellagic acid all of which demonstrated abilities in suppressing cancer development in many recent cancer studies. The focus of this study was to investigate the effect of WPE on human colon cancer stem cells and on the colon cancer cells from the cancer cell line HCT116. The purpose of this experiment was to find out how the walnut phenolic contents affect cancer stem cells’ survivability and how they induce the cancer cells to carry out apoptosis (cell-death).

Due to the synergistic effects of the individual phenolic compound in the “Walnut Phenolic Extract”, researchers found that “Walnut Phenolic Extract” was more effective in suppressing cell growth than individual phenolic compounds identified and experimented.

The researchers were able to confirm the ability of “Walnut Phenolic Extract” to suppress cancer stem cell’s self-renewal capability by measuring the size and number of the cancer spheres that formed from the cancer stem cells. With the exposure to the “Walnut Phenolic Extract” for 6 days, the sphere formation was suppressed by up to 72% compared to the untreated control stem cells.

The discoveries are very significant as the results showed that the phenolic, along with the bioactive compounds of walnut can suppress the cancer stem cells activities. The compounds also prevent the cancer cell from performing self-renewal.

Two very important notes about this experiment are that: all cancer stem cells and cancer cells have a maximum of 6 days of exposure to the “Walnut Phenolic Extract” during the experiment. The experiment results showed that cancer growth suppression is dose-dependent, which means the more walnut phenolic and bioactive compounds, the better results may reveal in controlling cancer growth and development. These results may also imply a possibility that a daily or regular consumption of walnut may help prevent and exterminate cancer in a gradual process. And this, of course, is my own opinion which may require further proving.

Medical Research #3 (published Feb 2016) [3]

Zinc is one of the major essential minerals that naturally exist in some food. It is required to initiate enzymatic reaction for over 300 enzymes in our body. It involves in DNA replication and transcription. It is a crucial element for normal immune system function; it promotes normal growth and development as it assists in protein, bone and DNA synthesis, wound healing and cell division. Zinc mineral is essential during all stages of our life including fetus, infancy, childhood, adulthood, old age and pregnancy for women. Our body does not store zinc. Therefore, daily consumption of food containing zinc is necessary to maintain good health.

In this study, the researchers combined walnut peptide (a protein chain) with zinc mineral in their cancer experiment. The purpose of this study was to investigate the effect of exposing a Walnut-Zinc compound, on various types of human cancer cells.

As many previous research studies showed that walnut peptide have detrimental effects on breast cancer cells, researcher took a synergistic approach in this experiment and combined zinc with walnut peptide to create walnut-zinc compound. Researcher selected human breast cancer cells from a cancer cell line, MCF-7 in this study.

During the lab test, the researcher exposes human breast cancer cells to a low concentration of the walnut-zinc compound, at 300 microgram per millimetre solution concentration for 48 hours. Their calculation revealed the cancer survival rate decreased to 20%. As the result, the cancer cells were also markedly reduced. The experiment concluded that walnut-Zinc compound can induce breast cancer cell apoptosis and cell cycle arrest.

Although it has been demonstrated that single nutrient such as zinc or bioactive component extracted from walnut is effective for cancer prevention, interactions between the different components within the food play an important role of the whole foods. This research demonstrated the hypothesis that a combination of nutrients or bioactive components increases the cancer cell apoptosis (cell death) effect, compared to an isolated compound.

It is very exciting to see the research scientists explored the use of other essential mineral such as zinc (which is naturally rich in walnut) to create a synergetic effect with walnut peptide to kill cancer in their experiment. I hope this helps you to understand the importance of using whole food and supplementation to strengthen your body’s capability in preventing and killing cancer.

Medical Research #4 (published July 2015) [4]

Guglone is a very potent growth suppressor. It exists in various types of nut trees including its roots. For centuries, walnut tree growers have known that where walnut tree grows, the surrounding root area would have an absence of weeds and any fruits or vegetables that grow in the surrounding ground would have very poor yield or die. With this knowledge, researchers, over the past decades, have extracted Guglone from walnut bark, leaves, fruits, etc to create herbicide, a weed killer.

Out of curiosity as to whether Guglone have any effect on human body cells, an experiment was carried out in 2015. Researchers extracted and isolated the chemical component Guglone from walnut tree roots. The study involved investigation on its cytotoxic activity along with its various analogs (synthesized / man-made Guglone type compound) on different human cancer cell lines.

Just as researchers expected, Guglone showed potent growth suppression and cytotoxic properties on various types of human cancer cells selected for the experiment.

What’s so amazing about this research experiment was that the results showed that Guglone, the extract of walnut tree roots, has potent anti-cancer suppressing/killing properties on 8 different human cancer cell lines. These cancer cell lines belong to 2 types of colon cancer (Colo-205, HCT-116), 1 type of breast cancer (T47D), 2 types of prostate cancer (PC-3 and DU-145), 1 type of skin cancer (A-431) and 2 types of lung cancers (NCI-H322 and A549).

With the knowledge that Guglone has a cancer killing effect, researchers created a synthetic form of Guglone in an attempt to patent and create a more powerful cancer killing drug. While the analog (synthetic Guglone) showed heightened cytotoxic effects on two Lung cancer cell lines, A549 and NCI-H322, to the researchers’ disappointment, the synthetic form of Guglone did not exhibit any cytotoxic effect on any other human cancer cells selected.

However, when comparing the cancer killing effects of synthetic Guglone with one of the most cytotoxic lung cancer chemotherapeutic drugs, BEZ-235, synthetic Guglone demonstrated superior cytotoxic potency. With the creation of synthetic Guglone, the researchers have another potential chemotherapeutic drug for their Lung Cancer research and treatment. Hopefully, this new drug would have less harmful side effects than the current BEZ-235 chemotherapeutic drug to the lung cancer patients.

Medical Research #5 (published November 2014) [5]

Walnut is naturally rich in ellagitannins (ETs), an anticancer polyphenol. Ellagitannins (ETs), once consumed, is hydrolyzed (breakdown into smaller molecules by chemical reaction with water) to release ellagic acid which is another very important anti-inflammatory and anticancer polyphenol.

Urolithins A and B are the metabolites (by products) of ellagic acid after they are digested by our normal intestinal flora. Urolithins A and B also happen to have anti-cancer properties and they proved to slow down the growth and proliferation of many types of cancer cells. However, the mechanisms remain unclear to the scientists.

In this experiment, researchers used Urolithins A (derived from the gut flora) to study the interaction between Urolithins and Prostate cancer cells, LNCaP. Specifically the researchers would like to understand the mechanisms that related to androgen receptor (AR), which have been linked to the development of LNCaP prostate cancer.

As expected, researchers were able to prove that the Urolithins compounds can weaken the androgen receptor (AR) function by suppressing it from conveying genetic information to Specific Antigen (PSA). Furthermore, the experiment showed that Urolithins induce cancer cell apoptosis (cell death).

So, what’s so special about this research?

This research result shows that by supporting our gut flora through consuming healthy foods such as walnut, our gut flora can reciprocate us anti-cancer substances such as Urolithins A and B. So, if we want to live a cancer free life, we should eat real food such as walnuts which supports our gut flora which in turn, support our health and promote longevity!

Based on medical research results, what cancer cells can be defeated by walnuts?                            

Based on the medical research results, walnuts may be used as an adjunct dietary cancer recovery plan to help fight 3 types of Breast cancer, 3 types of colon cancer, 1 type of cancer stem cell, 2 types of lung cancer, 3 types of prostate cancer and 1 type of skin cancer.

Nutrition value and cancer fighting effect at a glance:

Disclaimer:

The purpose of this article is to present clinical data to the general public in a way which make it easier to understand the scientific and therapeutic views of food/herbs. The author of this article does not endorse any brand supplement or products mentioned in this article.

This blog post was written as the result of my active research study for adjunct cancer treatment for my existing cancer patients to fight cancer. Thank you for reading this article. Please click the share button on this page if you feel that this article may be of interest to others in their cancer fighting journey.

About the Author:

Bernadette Yu is registered Traditional Chinese Medicine Practitioner and Holistic Nutritionist within Ontario, she teaches Chinese Herbal medicine in one of the Chinese Medicine Schools in Toronto. She enjoys reading medical journals and experiment with food and herbs in her kitchen. She is a frequent speaker/presenter in topics related to Chinese Medicine and holistic nutrition. She gives seminars on a regular basis in the general public to promote the use of Chinese Medicine and dietary therapy as an adjunct therapy to treat various types of diseases in a natural way.

[1] Antioxidant and Anticancer Activities of Walnut (Juglans regia L.) Protein Hydrolysates Using Different Proteases.

^[2] Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness.

^[3] Synthesis and Characterization of a Walnut Peptides-Zinc Complex and Its Antiproliferative Activity against Human Breast Carcinoma Cells through the Induction of Apoptosis.

^[4] Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines.

^[5] Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells.

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